2023
59) S. Ali Akbari Ghavimi*, M.R. Aronson*, R.M. Friedman, D.D. Ghaderi, N. Patel, T. Giordano, R.C. Borek, C.M. Devine, L. Han, I.N. Jacobs, R. Gottardi. Modulated Fibrosis and Mechanosensing of Fibroblasts by SB525334 in Pediatric Subglottic Stenosis. The Laryngoscope. 2023, 103(1): 287-296 DOI:10.1002/lary.30873.
58) M.R. Aronson, A. Mehta, R.M. Friedman, D.D. Ghaderi, R.C. Borek, H.C.B. Nguyen, K.S. McDaid, I.N. Jacobs, N. Mirza, R. Gottardi. Amelioration of Subglottic Stenosis by Antimicrobial Peptide Eluting Endotracheal Tubes. Cellular and Molecular Bioengineering. 2023. DOI: 10.1007/s12195-023-00769-9 Accepted - available online ahead of print.
57) I. Chiesa, C. De Maria, G. Vozzi, R. Gottardi. Three-dimensional and Four-dimensional Printing in Otolaryngology. MRS Bulletin. 2023. MRS Bulletin. 2023, 48: 1-12. DOI: 10.1557/s43577-023-00544-1
56) J.M. Collins, A. Lang, C. Parisi, Y. Moharrer, M.P. Nijsure, J.H. Kim, G.L. Szeto, L. Qin, R. Gottardi, N. Dyment, N. Nowlan, J.D. Boerckel. YAP and TAZ couple osteoblast precursor mobilization to angiogenesis and mechanoregulated bone development. Developmental Cell. 2023, DOI: 10.1016/j.devcel.2023.11.029 Accepted, in press, available ahead of print.
2022
55) P. Gehret, S. Ali Akbari Ghavimi, A. Dumas, R.C. Borek, M. Aronson, K. Carpenter, I.N. Jacobs, R. Gottardi. A Translational Tissue Engineering Approach to Airway Reconstruction Leveraging Decellularized Meniscus and Cartilage Progenitor Cells. bioRxiv. 2022, DOI: 10.1101/2022.12.13.520352
54) M.T. Raimondi, B. Barzaghini, A. Bocconi, C. Conci, C. Martinelli, A. Nardini, C. Testa, S. Carelli, G. Cerullo, G. Chirico, R. Gottardi, R. Osellame, A. Remuzzi, M. Laganà, E, Jacchetti. Micro structured tools for cell modeling in the fourth dimension. Proc. of SPIE 11786T DOI: 10.1117/12.2593332
53) S. Ali Akbari Ghavimi, P.M. Gehret, T. Giordano, K.W.Y. Smith, R. Gottardi. Human cartilage progenitor cells from ear, nose, rib, and joint have a robust, stable phenotype for cartilage repair. bioRxiv. 2022, 498323; DOI: 10.1101/2022.06.30.498323
52) I. Chiesa, R. Di Gesù, K.J. Overholt, R. Gottardi. A Mesoscale 3D Culture System for Native and Engineered Biphasic Tissues: Application to the Osteochondral Unit. In: Rasponi M. (eds) Organ-on-a-Chip. Methods in Molecular Biology, vol 2373: 267-281. Humana, New York, NY. DOI: 10.1007/978-1-0716-1693-2_16
51) M.R. Aronson, S. AliAkbariGhavimi, P.M. Gehret, I.N. Jacobs, R. Gottardi. Drug-eluting Endotracheal Tubes for Preventing Bacterial Inflammation in Subglottic Stenosis. The Laryngoscope. 2022, 132:1356–1363. DOI: 10.1002/lary.29769
2021
50) S. Ali Akbari Ghavimi, P.M. Gehret, M.R. Aronson, R. Schipani, K.W.Y. Smith, R.C. Borek, J.A. Germiller, I.N. Jacobs, K.B. Zur, R. Gottardi. Drug Delivery to the Pediatric Upper Airway. Advanced Drug Delivery Reviews. 2021, 174:168-189. DOI: 10.1016/j.addr.2021.04.004
49) J.L. Handlos, A. Esrafili, J.L. Mangal, S. Inamdar, S. Mcmillian, M. Wankhede, R. Gottardi, A.P. Acharya. Engineering metabolism of chimeric antigen receptor (CAR) cells for developing efficient immunotherapies. Cancers. 2021, 13(5):1123. DOI: 10.3390/cancers13051123
48) E. Capuana, D. Marino, R. Di Gesù, V. La Carrubba, V. Brucato, R.S. Tuan, R. Gottardi. A High-Throughput Mechanical Activator for Cartilage Engineering Enables Rapid Screening of in vitro Response of Tissue Models to Physiological and Supra-physiological Loads. Cells, Tissues, Organs. 2021, 14:1-19. DOI: 10.1159/000514985
47) A. Pirosa*, R. Gottardi* co-first author, P.G. Alexander, D. Puppi, F. Chiellini, R.S. Tuan. An in vitro chondro-osteo-vascular triphasic model of the osteochondral complex. Biomaterials. 2021, 272:120773. DOI: 10.1016/j.biomaterials.2021.120773
46) R. Gottardi, K. Moeller, R. Di Gesù, R.S. Tuan, M. van Griensven, E.R. Balmayor. Application of a Hyperelastic 3D Printed Scaffold for Mesenchymal Stem Cell-based Fabrication of a Bizonal Tendon Enthesis-like Construct. Frontiers in Materials: Biomaterials. 2021, vol 8, article 613212. DOI:10.3389/fmats.2021.613212
45) A.C. Greene, A.P. Acharya, S.B. Lee, R. Gottardi, E. Zaleski, S.R. Little. Cranberry extract-based formulations for preventing bacterial biofilms. Drug Delivery and Translational Research. 2021, 11:1144–1155. DOI: 10.1007/s13346-020-00837-x.
2020
44) R. Gottardi. Advances in bioprinting: a toolbox for tissue engineering. Connective Tissue Research. 2020, 61(2):115-116. DOI: 10.1080/03008207.2020.1715573.
43) R.M. Haley, R. Gottardi, R. Langer, M.J. Mitchell. Cyclodextrins in Drug Delivery: Applications in Gene and Combination Therapy. Drug Delivery and Translational Research. 2020, 10:661–677 DOI:10.1007/s13346-020-00724-5
42) I. Chiesa, C. De Maria, A. Lapomarda, G.M. Fortunato, F. Montemurro, R. Di Gesù, R.S. Tuan, G. Vozzi, R. Gottardi. Endothelial cells support osteogenesis in an in vitro vascularized bone model developed by 3D bioprinting. Biofabrication. 2020, 12(2):025013 DOI: 10.1088/1758-5090/ab6a1d.
41) A. Lapomarda, A. De Acutis, I. Chiesa, G.M. Fortunato, F. Montemurro, C. De Maria, M. Mattioli Belmonte, R. Gottardi, G. Vozzi. Pectin-GPTMS based biomaterial: toward a sustainable Bioprinting of 3D scaffolds for Tissue Engineering application. Biomacromolecules. 2020, 21(2):319-327. DOI: 10.1021/acs.biomac.9b01332
40) R. Di Gesù, A. Acharya, I. Jacobs, R. Gottardi. 3D Printing for Tissue Engineering in Otolaryngology. Connective Tissue Research. 2020, 61(2):117-136. DOI: 10.1080/03008207.2019.1663837
2019
39) R. Di Gesù, G. Amato, R. Gottardi. Electrospun Scaffolds in Tendons Regeneration: a review. Muscles, Ligaments and Tendons Journal. 2019, 9(4): 478-493
38) B.B. Rothrauff, H. Sasaki, S. Kihara, K.J. Overholt, R. Gottardi, H. Lin, F.H. Fu, R.S. Tuan, P.G. Alexander. Point-of-Care Procedure for Enhancement of Meniscal Healing in a Goat Model Utilizing Infrapatellar Fat Pad-derived Stromal Vascular Fraction Cells in Photocrosslinkable Hydrogel. American Journal of Sports Medicine. Accepted. DOI: 10.1177/0363546519880468
37) N. Joseph, H.D. Lawson, K.J. Overholt, K. Damodaran, R. Gottardi, A.P. Acharya, S.R. Little. Synthesis and characterization of CaSr-Metal Organic Frameworks for biodegradable orthopedic applications. Scientific Reports. 2019, 9(1):13024. DOI: 10.1038/s41598-019-49536-9
36) R. Gottardi. Load-induced osteoarthritis on a chip. Nature Biomedical Engineering. 2019, 3:502-503, DOI: 10.1038/s41551-019-0427-y
35) T. Iseki, B.B. Rothrauff, S. Kihara, H. Sasaki, S. Yoshiya, F.H. Fu, R.S. Tuan, R. Gottardi. Dynamic Compressive Loading Improves Cartilage Repair in an in vitro Model of Microfracture: Comparison of Two Mechanical Loading Regimens on Simulated Microfracture Based on Fibrin Gel Scaffolds Encapsulating Connective Tissue Progenitor Cells. American Journal of Sports Medicine. 2019, 47(9):2188-2199, DOI:10.1177/0363546519855645
2018
34) R. Gottardi, M. Stoddart. Regenerative rehabilitation of the musculoskeletal system. Journal of the American Academy of Orthopaedic Surgeons. 2018, 26(15): e321-e323, DOI: 10.5435/JAAOS-D-18-00220
33) H. Sasaki, B.B. Rothrauff, P.G. Alexander, H. Lin, R. Gottardi, F.H. Fu, R.S. Tuan. In vitro repair of meniscus radial tear using hydrogels seeded with adipose stem cells and TGF-β3. American Journal of Sports Medicine. 2018, 46(10): 2402-2413, DOI: 10.1177/0363546518782973
32) P.N. Mittwede, R. Gottardi, P.G. Alexander, I.S. Tarkin, R.S. Tuan. Clinical Applications of Bone Tissue Engineering in Orthopaedic Trauma. Current Pathobiology Reports. 2018, 6(2): 99–108, DOI: 10.1007/s40139-018-0166-x.
31) L. Coluccino*, R. Gottardi* co-first author, F. Ayade, A. Athanassiou, R.S. Tuan, L. Ceseracciu. Porous Poly(vinyl alcohol)-Based Hydrogel for Knee Meniscus Functional Repair. ACS Biomaterials Science & Engineering. 2018, 4(5): 1518–1527, DOI: 10.1021/acsbiomaterials.7b00879
30) A. Pirosa, R. Gottardi, P.G. Alexander, R.S. Tuan. Engineering in vitro vascularized bone models for drug screening and predictive toxicology. Stem Cell Research & Therapy. 2018, 9: 112. DOI: 10.1186/s13287-018-0847-8
29) D.A. Nichols, I.S. Sondh, S.R. Little, P. Zunino, R. Gottardi@ corresponding author. Design and validation of an osteochondral bioreactor for the screening of treatments for osteoarthritis. Biomedical Microdevices. 2018, 20: 18. DOI: 10.1007/s10544-018-0264-x
2017
28) M.L. Ratay. E. Bellotti, R. Gottardi, S.R. Little. Modern Therapeutic Approaches for Ocular Diseases Involving Inflammation. Advanced Healthcare Materials. 2017, 6(2):1700733. DOI: 10.1002/adhm.201700733
· Article featured on the Journal Cover.
27) E. Bayer, J. Jordan, A. Roy, R. Gottardi, M.V. Fedorchak, P. Kumta, S.R. Little. Programmed PDGF-BB and BMP-2 Delivery from a Hybrid, Calcium Phosphate/ Alginate Scaffold. Tissue Engineering. 2017, 23(23-24): 1382-1393. DOI: 10.1089/ten.TEA.2017.0027
· Article featured on the Journal Cover.
26) B.B. Rothrauff, L. Coluccino, R. Gottardi, L. Ceseracciu, S. Scaglione, L. Goldoni, R.S. Tuan. Efficacy of thermoresponsive, photocrosslinkable hydrogels derived from decellularized tendon and cartilage extracellular matrix for cartilage tissue engineering. Journal of Tissue Engineering and Regenerative Medicine. 2017, 12(1):e159-e170. DOI: 10.1002/term.2465.
25) L. Coluccino, C. Peres, R. Gottardi, P. Bianchini, A. Athanassiou, A. Diaspro, L. Ceseracciu. Anisotropic Viscoelastic Biomechanical Mapping of Knee Meniscus Cartilage. Journal of Applied Biomaterials & Functional Materials. 2017, 15(1): e77-e83. DOI: 10.5301/jabfm.5000319
2016
24) B.B. Rothrauff, K. Shimomura, R. Gottardi, P.G Alexander, R.S. Tuan. Anatomical region-specific enhancement of 3-dimensional chondrogenic differentiation of human mesenchymal stem cells by soluble meniscus extracellular matrix. Acta Biomaterialia. 2017, 49:140-151. DOI: 10.1016/j.actbio.2016.11.046
23) P.-o. Numpaisal, B.B. Rothrauff, R. Gottardi, C.-L. Chien, R.S. Tuan. Rapidly dissociated autologous meniscus tissue to enhance meniscus healing: an in vitro study. Connective Tissue Research. 2017, 58(3-4):355-365. DOI: 10.1080/03008207.2016.1245727
22) R. Gottardi, U. Hansen, R. Raiteri, M. Loparic, M. Düggelin, D. Mathys, N.F. Friederich, P. Bruckner, and M. Stolz. Supramolecular organization of collagen fibrils in healthy and osteoarthritic human knee- and hip joint cartilage. PLoS ONE. 2016, 11(10): e0163552. DOI: 10.1371/journal.pone.0163552
21) L. Iannetti, G. D’Urso, G. Conoscenti, E. Cutrì, R.S. Tuan, M.T. Raimondi, R. Gottardi, P. Zunino. Distributed and lumped parameter models for the characterization of high throughput bioreactors. PLoS ONE. 2016, 11(9): e0162774. DOI: 10.1371/journal.pone.0162774
20) A.X. Sun, P.-o. Numpaisal, R. Gottardi, H. Shen, G. Yang, R.S. Tuan. Cell and Biomimetic Scaffold Based Approaches for Cartilage Regeneration. Operative Techniques in Orthopaedics. 2016, 26(3): 135–146. DOI: 10.1053/j.oto.2016.06.003
19) Jr-Jiun J. Liou, M.T. Langhans, R. Gottardi, R.S. Tuan. Injury and Repair of Tendon, Ligament and Meniscus. Chapter 6 in: Translating Regenerative Medicine to the Clinic edited by J. Laurence, P. Baptista, A. Atala and M. Van Beusekom. Academic Press, Elsevier, 2016: 75-88.
2015 & earlier
18) R. Gottardi. Towards a minimally invasive sampling tool for high resolution tissue analytical mapping. Nanotechnology. 2015, 26, 372501-4. DOI: 10.1088/0957-4484/26/37/372501
17) M. Guaragno, R. Gottardi, M.V. Fedorchak, A. Roy, P. Kumta, S.R. Little. One-Step Synthesis of Fluorescently Labeled Single-Walled Carbon Nanotubes. Chemical Communications. 2015, 51, 17233-17236. DOI: 10.1039/c5cc05573c
16) E. Bayer, R. Gottardi, M.V. Fedorchak, S.R. Little. The Scope and Sequence of Growth Factor Delivery for Vascularized Bone Tissue Regeneration. Journal of Controlled Release. 2015, 219: 129-140. DOI: 10.1016/j.jconrel.2015.08.004
15) M. Taffetani, R. Raiteri, R. Gottardi, D. Gastaldi, P. Vena. A quantitative interpretation of atomic force microscopy based dynamic nanoindentation tests on articular cartilage. Journal of Biomechanical Engineering. 2015, 137(7), 071005-1:8. DOI: 10.1115/1.4030175
14) A.J. Glowacki, R. Gottardi, S. Yoshizawa, F. Cavalla, G.P. Garlet, C. Sfeir, S.R. Little. Strategies to direct the enrichment, expansion, and recruitment of regulatory cells for the treatment of disease. Annals of Biomedical Engineering. 2015, 43(3): 593-602. DOI: 10.1007/s10439-014-1125-2
13) A. D'Amore, N. Amoroso, R. Gottardi, C. Hobson, C. Carruthers, S. Watkins, W. Wagner, M. Sacks. From single fiber to macro-level mechanics: A structural finite-element model for elastomeric fibrous biomaterials. Journal of the Mechanical Behavior of Biomedical Materials. 2014, 39: 146-161. DOI: 10.1016/j.jmbbm.2014.07.016
12) M. Taffetani, R. Gottardi, D. Gastaldi, R. Raiteri, P. Vena. Poroelastic response of articular cartilage by nanoindentation creep tests with different characteristic sizes. Medical Engineering & Physics. 2014, 36(7): 850-858. DOI: 10.1016/j.medengphy.2014.03.008
11) H. Lin, T.P. Lozito, P.G. Alexander, R. Gottardi, R.S. Tuan. Stem Cell-based Microphysiological Osteochondral System to Model Tissue Response to Interleukin-1β. Molecular Pharmaceutics. 2014, 11(7): 2203-12. DOI: 10.1021/mp500136b
10) P.G. Alexander*, R. Gottardi* co-first author, H. Lin, T.P. Lozito, R.S. Tuan. Three Dimensional Osteogenic and Chondrogenic Systems to Model Osteochondral Physiology and Degenerative Joint Diseases. Experimental Biology and Medicine. 2014, 239: 1080-1095. DOI: 10.1177/1535370214539232
9) K. Kamalasanan*, R. Gottardi* co-first author, S. Tan, Y. Chen, B. Godugu, S. Rothstein, A.C. Balazs, A. Star, S.R. Little. “Zero Dimensional” Single Walled Carbon Nanotubes. Angewandte Chemie. 2013, 52(43): 11308-11312. DOI: 10.1002/anie.201305526
8) T.P. Lozito, P.G. Alexander, H. Lin, R. Gottardi, A.W.-M. Cheng, R.S. Tuan. Three-dimensional osteochondral microtissue to model pathogenesis of osteoarthritis. Stem Cell Research & Therapy. 2013, 4(Suppl 1):S6. DOI: 10.1186/scrt367
7) G. Yang, B.B. Rothrauff, H. Lin, R. Gottardi, P.G. Alexander, R.S. Tuan. Enhancement of Tenogenic Differentiation of Human Adipose Stem Cells by Tendon-Derived Extracellular Matrix. Biomaterials. 2013, 34(37): 9295-306. DOI: 10.1016/j.biomaterials.2013.08.054
6) R. Gottardi*, B. Douradinha*. Carbon nanotubes as a novel tool for vaccination against infectious diseases and cancer. Journal of Nanobiotechnology. 2013, 11:30 *equal contribution. DOI: 10.1186/1477-3155-11-30
5) W.R. Thompson, R. Gottardi, K.M. Stearns, J. Rubin, F. Ambrosio, R.S. Tuan. Biologics in Cartilage, Bone Repair, and Regeneration. In: Hughes C, ed. ISC 23.2, Applications of Regenerative Medicine to Orthopaedic Physical Therapy. La Crosse, WI: Orthopaedic Section APTA; 2013.
4) M. Taffetani, E. Bertarelli, R. Gottardi, R. Raiteri, and P. Vena. Modeling of the Frequency Response to Dynamic Nanoindentation of Soft Hydrated Anisotropic Materials: Application to Articular Cartilage. Computer Modeling in Engineering & Science. 2012, 87, 5 433-460.
3) M. Stolz, R. Gottardi, R. Raiteri, S. Miot, I. Martin, R. Imer, U. Staufer, A. Raducanu, M. Düggelin, W. Baschong, A.U. Daniels, N. F. Friederich, A. Aszodi, U. Aebi. Early detection of osteoarthritic and aging articular cartilage in mice and patient samples using AFM. Nature Nanotechnology. 2009, 4:186-192. DOI: 10.1038/nnano.2008.410
2) A. Marsano, D. Wendt, R. Raiteri, R. Gottardi, M. Stolz, D. Wirz, A.U. Daniels, D. Salter, M. Jakob, T.M. Quinn, I. Martin. Use of hydrodynamic forces to engineer cartilaginous tissues resembling the non-uniform structure and function of meniscus. Biomaterials. 2006, 27: 5927-5934. DOI: 10.1016/j.biomaterials.2006.08.020
1) C. Ascoli, R. Gottardi, D. Petracchi, 2004. Scanning probe microscopy. In: Lasers and current optical techniques in biology, edited by Giuseppe Palumbo and Riccardo Pratesi, London: The Royal Chemical Society, 2004: 375-427